2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115420
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E)) is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides.
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
  • HY-172569
    (±)8(9)-EET Ethanolamide
    (±)8(9)-EET Ethanolamide is a CYP450 metabolite of Arachidonic acid (HY-109590). (±)8(9)-EET Ethanolamide induces preglomerular vasoconstriction.
    (±)8(9)-EET Ethanolamide
  • HY-134998
    Oltipraz metabolite M2
    Oltipraz metabolite M2, an active metabolite of Oltipraz (HY-12519), is an orally active HIF-1α inhibitor. Oltipraz metabolite M2 increases mitochondrial fuel oxidation and inhibits lipogenesis in the liver by dually activating AMPK in high-fat diet (HFD)-fed mice. Oltipraz metabolite M2 can be used for hepatic steatosis and steatohepatitis research.
    Oltipraz metabolite M2
  • HY-W777322
    3,4-Dihydroxybenzeneacetic acid-13C,18O2
    3,4-Dihydroxybenzeneacetic acid-13C,18O2 is the 13C- and 18O-labeled labeled 3,4-Dihydroxybenzeneacetic acid (HY-W001080). 3,4-Dihydroxybenzeneacetic acid is the main neuronal metabolite of dopamine.
    3,4-Dihydroxybenzeneacetic acid-<sup>13</sup>C,<sup>18</sup>O<sub>2</sub>
  • HY-W727031
    2-Methylamino-1-phenylbutane hydrochloride
    		99.28%
    2-Methylamino-1-phenylbutane hydrochloride is a metabolite of stimulant agents in blood.
    2-Methylamino-1-phenylbutane hydrochloride
  • HY-113879
    18-Carboxy dinor Leukotriene B4
    18-Carboxy dinor Leukotriene B4 (18-carboxy dinor LTB4) is a β-oxidation metabolite of LTB4. In the liver, LTB4 is rapidly metabolized to 20-carboxy LTB4, which then undergoes β-oxidation to 18-carboxy dinor LTB4.
    18-Carboxy dinor Leukotriene B4
  • HY-W192276
    (±)-Desisopropylpropranolol
    (±)-Desisopropylpropranolol (N-Desisopropylpropranolol) is a metabolite of Propranolol (HY-B0573B). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Kis of 1.8 nM and 0.8 nM, respectively. Propranolol inhibits [3H]-DHA binding to rat brain membrane preparation with an IC50 of 12 nM. Propranolol is used for the study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy.
    (±)-Desisopropylpropranolol
  • HY-137532
    7-Hydroxyquetiapine
    7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].
    7-Hydroxyquetiapine
  • HY-W002112R
    (±)-Nornicotine (Standard)
    (±)-Nornicotine (Standard) is the analytical standard of (±)-Nornicotine (HY-W002112). This product is intended for research and analytical applications. (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
    (±)-Nornicotine (Standard)
  • HY-W654323
    PNU-142586 sodium
    PNU-142586 sodiu) is the major metabolite of Linezolid (HY-10394). PNU-142586 can inhibit the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). PNU-142586 interferes with DNA replication and transcription by blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, ultimately leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. PNU-142586 can be used to study Linezolid-induced hematotoxicity and its molecular mechanism.
    PNU-142586 sodium
  • HY-131253
    Febuxostat isopropyl isomer
    Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat isopropyl isomer
  • HY-130569A
    7-Hydroxymethotrexate sodium
    7-Hydroxymethotrexate sodium is a major metabolite of Methotrexate (HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis.
    7-Hydroxymethotrexate sodium
  • HY-W707158
    Norfenfluramine hydrochloride
    Norfenfluramine hydrochloride ((±)-Norfenfluramine hydrochloride) is a major and brain-penetrant metabolite of Fenfluramine. Norfenfluramine hydrochloride can interact with 5-HT transporters to release 5-HT from neurons. Norfenfluramine hydrochloride displays antiepileptic effects in vivo.
    Norfenfluramine hydrochloride
  • HY-103252R
    Monomethyl fumarate (Standard)
    Monomethyl fumarate (Standard) is the analytical standard of Monomethyl fumarate. This product is intended for research and analytical applications. Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease[1][2][3].
    Monomethyl fumarate (Standard)
  • HY-B1342A
    13-cis-Vitamin A
    13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter.
    13-cis-Vitamin A
  • HY-P3006
    Des-Leu10-angiotensin I
    Des-Leu10-angiotensin I is a nonapeptide that inhibits rabbit lung angiotensin-converting enzyme peptidyl-dipeptide hydrolase with a Ki value of 31 μM, which is generated from angiotensin I by the action of carboxypeptidase-like activities residing in the human platelet and mast cell.
    Des-Leu10-angiotensin I
  • HY-Z1430S
    (3R,4S)-Paroxetine-d4 hydrochloride
    Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine (Paroxetine Impurity).
    (3R,4S)-Paroxetine-d<sub>4</sub> hydrochloride
  • HY-160849
    N-Desmethyl Rilmazolam
    		Inhibitor
    N-Desmethyl Rilmazolam is a metabolite of Rilmazolam (HY-150334) and 450191-S (HY-U00228). N-Desmethyl Rilmazolam significantly enhances the activity of 7-ethoxycoumarin O-deethylase. N-Desmethyl Rilmazolam can be used in insomnia-related studies.
    N-Desmethyl Rilmazolam
  • HY-N12843
    2-Deoxokanshone M
    2-Deoxokanshone M (Nardosinone acid) is a degradation product of Nardosinone (HY-N0380) and has potent vasodilatory activity.
    2-Deoxokanshone M
  • HY-117934
    Isokotanin B
    Isokotanin B is a metabolite of bicoumarin isolated from the sclerotia of Aspergillus alliaceus. Isokotanin B shows activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus.
    Isokotanin B
Cat. No. Product Name / Synonyms Application Reactivity